By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the great physique of simple technology and scientific facts linked to adenomatous polyps of the colon, a lot of it encouraged by way of the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing topics. subject matters comprehensively explored comprise anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant power of adenomatous polyps; and detection and administration, with precise recognition to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
Gastrointest Endosc 27(1):185-186. ClarkJC, Collan Y, Eide TN, EsteveJ, Ewen S, Gibbs NM, Jensen OM (1985) Prevalence of polyps in an autopsy series from areas with varying incidence of large-bowel cancer. Int J Cancer 36:179-186. Cole JW, Holden WD (1959) Postcolectomy regression of adenomatous polyps ofthe rectum. AMA Arch Surg 79:385-392. References 37 Cole J, McKalen A (1963) Studies on the morphogenesis of adenomatous polyps in the human colon. Cancer 16:998-1002. Cooper HS, Cox J, Patchefsky AS (1980) Immunohistologic study of blood group substances in polyps of the distal colon: Expression of a fetal antigen.
Connective tissue tumors originating in the submucosa or muscularis propria, or lymphomas, may also present as polyps, but the presence of intact overlying mucosa usually permits recognition of their nonepithelial origin. Other Characteristics of Polyps 25 E. , 1971). ) Being thus devoid of neoplastic potential, it was felt that such lesions did not have to be excised. However, the polyps examined by Lane et ai. were < 3 mm, whereas diminutive polyps by definition are < 5 mm. , 1986). Several authors have emphasized that a significantly higher percentage of polyps in the 4-5 mm range are adenomatous than those between 1 and 3 mm.
H&E; x 88, reproduced at 100%. 21. Mildly dysplastic tubular adenoma (typical glands best seen in lower left and far right) showing changes in several upper crypts (arrows) resembling those found in hyperplastic polyps. H&E; x22, reproduced at 100%. 22. 21. The upper crypts show infoldings of eosinophilic cytoplasm (long arrows) that are similar to those found in classical hyperplastic polyps. Papillary infoldings in the deeper crypts of more basophilic cells (short arrows) showing some loss of nuclear polarity probably represent proliferation of truly adenomatous epithelium and contrast with the smooth-walled deep crypts in hyperplastic polyps.