By F. Lang, M. Ritter, H. Völkl, D. Häussinger (auth.), Prof. Dr. Florian Lang, Prof. Dr. Dieter Häussinger (eds.)
One of the must haves for survival is the power of cells to take care of their quantity. hence, in the course of the process evolution cells have "learned" numerous concepts to accomplish quantity homeostasis. This quantity regulatory equipment includes rules of either, mobile metabolism and mobile shipping and is exploited by way of hormones and transmitters to control cellularfunction. This e-book to illustrates the complicated interaction of cellphone quantity regulatory mechanisms and mobile functionality in quite a few tissues. notwithstanding, our wisdom remains to be faraway from being conclusive, and the current selection of reports is assumed to foster additional experimental efforts to solve the position of cellphone quantity within the built-in functionality of cells.
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Additional info for Advances in Comparative and Environmental Physiology: Interaction of Cell Volume and Cell Function
System A activity is increased during starvation, feeding of a high protein diet and by hormones such as glucagon and insulin, whereas system N is much less responsive to starvation (Hayes and McGivan 1982). The Na+ -dependent transporters build up intra/extracellular amino acid concentration gradients of up to 20. Na+ entering the hepatocyte together with the amino acid is extruded in exchange for K+ by the electrogenic Na+ /K+ ATPase. The accumulation of amino acids and K+ into the cells leads to hepatocyte swelling, which in turn triggers volume regulatory K+ efflux (Kristensen 1980; Bakker-Grunwald 1983; Kristensen and Folke 1984, 1986; Hiiussinger et al.
J Gen Physiol69: 537-552 Cala PM (1980) Volume regulation by Amphiuma red blood cells. The membrane potential and its implications regarding the nature of the ion-flux pathways. J Gen Physiol 76: 683-708 Cala PM (1983) Cell volume regulation by Amphiuma red blood cells. The role of Ca2 + as a modulator of alkali metalIH+ exchange. J Gen Physiol 82: 761-784 Cala PM (1985) Volume regulation by Amphiuma red blood cells: characteristics of volume-sensitive K/H and Na/H exchange. Mol Physiol 8: 199-214 Cala PM, Mandel U, Murphy E (1986) Volume regulation by Amphiuma red blood cells: cytosolic free Ca and alkali metal-H exchange.
Hiiussinger 1 , W. Gerokl, and F. Lang2 Contents 1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Cell Volume Control in Liver ............................................ 1 Anisoosmotic Cell Volume Modulation ................................... 2 Cumulative Substrate Transport ......................................... 3 Cell Volume Control by Hormones ....................................... 3 Modulation of Hepatic Metabolism by Cell Volume ........................