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Amebiasis: Biology and Pathogenesis of Entamoeba by Tomoyoshi Nozaki, Alok Bhattacharya

By Tomoyoshi Nozaki, Alok Bhattacharya

This booklet records and provides new advancements within the learn of amebiasis, one of many overlooked tropical ailments. approximately 50 million humans world wide are contaminated with the pathogen Entamoeba histolytica, inflicting large-scale morbidity and mortality relatively in constructing nations. This ebook might help clinicians for greater analysis and administration of the affliction, researchers for starting up learn initiatives on a number of the poorly understood points of the disorder and the pathogen, and scholars for updating their wisdom. the topics lined diversity from genomics and molecular and mobile biology to drug resistance and new drug improvement, highlighting significant advances lately in our realizing as a result of fast growth in genomic and different biomedical applied sciences, comparable to visualization of molecular procedures. many of the chapters supply contemporary details according to most modern guides. a number of chapters describe a few of the serious methodological matters that may be important for college kids and researchers drawn to moving into the sector. The contributing authors comprise just about all the lively researchers and clinicians from around the globe. This booklet might be an invaluable fundamental fabric and a useful resource of knowledge for a person drawn to realizing amebiasis, its prognosis, and therapy. it is going to even be precious to people who have an interest in studying concerning the biology of early branching eukaryotes and protist pathogens.

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Approximately 20 % of the E. histolytica genome assembly is estimated to consist repetitive elements, which tend to be found in clusters in the genome [84]. Many of the genome sequence scaffolds are flanked by these elements, which might partly explain its fragmentary nature. Transposable elements might also act as sites of chromosomal instability, leading to structural changes in the chromosomes that can be seen as breaks in the synteny of genes between E. histolytica and E. dispar [84]. Among Entamoeba species, striking differences in transposon content are seen.

Am J Trop Med Hyg 79(5):706–707 30. Clark CG, Alsmark UC, Tazreiter M, Saito-Nakano Y, Ali V, Marion S, Weber C, Mukherjee C, Bruchhaus I, Tannich E, Leippe M, Sicheritz-Ponten T, Foster PG, Samuelson J, Noël CJ, Hirt RP, Embley TM, Gilchrist CA, Mann BJ, Singh U, Ackers JP, Bhattacharya S, Bhattacharya A, Lohia A, Guillén N, Duchêne M, Nozaki T, Hall N (2007) Structure and content of the Entamoeba histolytica genome. Adv Parasitol 65:51–190 31. Diamond LS, Mattern CF, Bartgis IL (1972) Viruses of Entamoeba histolytica.

Histolytica genome, which also presents a challenge for genome sequencing, as is discussed in the next section (Sect. 4). 4 Why Is Entamoeba Genome Assembly So Challenging? All Entamoeba genomes sequenced to date should be considered draft assemblies. They generally consist of a large number of scaffolds (>1,000) that are not assigned to chromosomes. Although E. histolytica and its relatives are not uniquely difficult genomes to sequence and assemble, they do present considerable challenges, which are discussed next.

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