By Hubert Schrezenmeier, Andrea Bacigalupo
This e-book takes account of the newest findings in laboratory study and scientific trials to supply a complete and updated reference at the pathophysiology, epidemiology, prognosis and therapy of got and inherited aplastic anemia. in addition to offering an in depth evaluate of the pathophysiology of the disorder, the overseas workforce of authors covers all features of administration, together with the proven techniques of bone marrow transplantation and immunosuppressive remedy, new techniques corresponding to using hematopoietic progress elements and escalated immunosuppression, and arguable concerns resembling stem mobilephone transplantation. additionally integrated is a vital overseas consensus record on remedy, and a last part concentrates at the inherited syndrome Fanconi's anemia. exact therapy directions are given, making this the definitive source for hematologists and different clinicians desirous about the administration and supportive care of sufferers with aplastic anemia. Scientists attracted to bone marrow failure also will locate this a useful reference.
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Additional info for Aplastic Anemia: Pathophysiology and Treatment
SCF levels were determined before and 2–3 months after BMT in 21 patients, all of whom achieved self-sustaining hemopoiesis. 005). , 1993), we did not observe that it had any value in predicting who would and would not respond to immunosuppressive therapy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) GM-CSF is a glycoprotein that has the potent eﬀects of stimulating the proliferation, maturation, and function of hemopoietic cells (Metcalf, 1986). GM-CSF can be synthesized by a variety of cell types in response to speciﬁc activating signals.
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L. and Zsebo, K. M. (1991) Primary structure and functional expression of rat and human stem cell factor DNAs. Cell, 63, 203–12. , Jordan, C. , Wiegand, G. , Pardoll, D. and Lemischka, I. R. (1991) A receptor tyrosine kinase speciﬁc to hematopoietic stem and progenitor cell-enriched populations. Cell, 65, 1143–52. McNiece, I. , Langley, K. E. and Zsebo, K. M. (1991) Recombinant human stem cell factor synergizes with GM-CSF, G-CSF, IL-3 and Epo to stimulate human progenitor cells of the myeloid and erythroid lineages.